Oxtellar XR® (oxcarbazepine) Dosing

These images are fictionalized for illustrative purposes only.

Dosing Options for Adult and Pediatric Patients 6 Years of Age and Older1


Oxtellar XR (oxcarbazepine) Dosing for Adults
Oxtellar XR (oxcarbazepine) Dosing for Pediatric Patients

Administering Oxtellar XR1

  • Oxtellar XR should be taken as a single daily dose on an empty stomach
    • Patients should take Oxtellar XR at least 1 hour before or at least 2 hours after meals
    • When Oxtellar XR is taken with food, adverse reactions are more likely to occur because of increased peak plasma concentration levels
  • Oxtellar XR tablets should be swallowed whole. Do not cut, crush, or chew the tablets
    • Lower-strength tablets (150 mg tablets) are available for pediatric patients or patients with difficulty swallowing
  • When converting from Trileptal® (oxcarbazepine) to Oxtellar XR, higher doses of Oxtellar XR may be necessary

Dosing Considerations1

  • Enzyme inducing antiepileptic drugs such as carbamazepine, phenobarbital, and phenytoin decrease the exposure to MHD, the active metabolite of Oxtellar XR. Dosage increases may be necessary
  • In patients with severe renal impairment, initiate Oxtellar XR at a lower starting dose and increase, if necessary, at a slower than usual rate until the desired clinical response is achieved
  • Concurrent use of Oxtellar XR with hormonal contraceptives and other oral or implant contraceptives may decrease plasma levels and render these contraceptives less effective. Additional non-hormonal forms of contraception are recommended

Reference

  1. Oxtellar XR [package insert]. Rockville, MD: Supernus Pharmaceuticals, Inc.; December 2015.